Tafalgan-MD 10 Tablets

Composition

Each mouth dissolving tablet contains:

• Celecoxib … 200 mg

Pharmacological Class

• Therapeutic Class: NSAID – COX-2 selective inhibitor

Mechanism of Action

Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins responsible for pain, inflammation, and fever, while sparing COX-1 to minimize gastrointestinal side effects compared to traditional NSAIDs.

Indications

Tafalgan™-MD is indicated for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Acute pain management (musculoskeletal pain, sprains, post-operative pain)

• Primary dysmenorrhea

• Chemo Metronomic therapy

Dosage & Administration

Adults:

• Usual dose: 200 mg once or twice daily, depending on the indication and severity of symptoms.

• Place the tablet on the tongue, allow it to dissolve, and swallow. No water is required.

Children:

• Not recommended below 18 years unless prescribed by a physician.

Elderly or Hepatic/Renal Impairment:

• Dose adjustment may be required.

Contraindications

• Hypersensitivity to celecoxib, sulfonamides, or any excipient in the formulation

• History of asthma, urticaria, or allergic-type reactions after taking aspirin/NSAIDs

• Pregnancy (especially third trimester) and lactation unless prescribed

• Severe hepatic or renal impairment

• Established cardiovascular disease (contraindicated in CABG surgery pain management)

Warnings & Precautions

• Risk of cardiovascular thrombotic events (MI, stroke)

• Gastrointestinal bleeding, ulceration, and perforation risk

• Caution in patients with hypertension, fluid retention, or edema

• Use lowest effective dose for shortest duration

• Not a substitute for corticosteroids in inflammatory conditions

Adverse Effects

• Common: Dyspepsia, diarrhea, abdominal pain, edema, headache, dizziness

• Rare: GI bleeding, severe allergic reactions, hepatotoxicity, renal impairment, cardiovascular events

  
  

Drug Interactions

• Anticoagulants (warfarin, DOACs) – ↑ bleeding risk

• ACE inhibitors, diuretics – may reduce antihypertensive effect

• Lithium – ↑ serum lithium levels

• Other NSAIDs – additive side effects

Storage

• Store below 30°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children